Prolog is a declarative programming language that is often used in artificial intelligence, natural language processing, and expert systems. It was developed in the 1970s by Alain Colmerauer and Philippe Roussel at the University of Aix-Marseille in France. Prolog stands for "Programming in Logic," which reflects its logic-based approach to problem-solving. In this guide, we will cover the basics of Prolog programming, including how to write Prolog code, an example of a simple program, and the best applications for the language.

Prolog Syntax and Structure
Prolog uses a different syntax and structure than traditional procedural languages like C++ and Java. Prolog programs consist of facts, rules, and queries. A fact is a statement that is always true, while a rule is a statement that is true under certain conditions. A query is a statement that asks if a particular condition is true.

Facts are written using the format `fact(argument1, argument2, ...).` For example, the fact `parent(john, mary).` states that John is Mary's parent. Rules are written using the format `head :- body.` The head is the condition that is true if the body is true. For example, the rule `grandparent(X, Z) :- parent(X, Y), parent(Y, Z).` states that X is a grandparent of Z if X is the parent of Y, and Y is the parent of Z.

Queries are written using the format `?- condition.` For example, the query `?- grandparent(john, mary).` asks if John is the grandparent of Mary.

Example Program
Here's an example of a simple Prolog program that defines some facts and rules about animals:

```
animal(lion).
animal(tiger).
animal(bear).
carnivore(lion).
carnivore(tiger).
omnivore(bear).
eats(X, Y) :- animal(X), carnivore(X), animal(Y).
```

This program defines three animals: a lion, a tiger, and a bear. It also defines that lions and tigers are carnivores, and bears are omnivores. The rule `eats(X, Y) :- animal(X), carnivore(X), animal(Y).` states that X eats Y if X is an animal, X is a carnivore, and Y is an animal. 

To test this program, we can ask some queries, for example:
```
?- carnivore(lion).
Yes

?- eats(lion, tiger).
Yes

?- eats(bear, lion).
No
```

Applications
Prolog has a wide range of applications due to its unique logic-based approach to problem-solving. It is commonly used in artificial intelligence and natural language processing, as well as expert systems, constraint programming, and database systems. Prolog is also used in various fields such as education, linguistics, and mathematics. 

One of the best-known applications of Prolog is the game of Sudoku, which can be solved using Prolog's constraint programming capabilities. Another application of Prolog is natural language processing, where it is used to parse and analyze human languages.

Conclusion
Prolog is a powerful and versatile programming language that is used in a variety of fields, from artificial intelligence to natural language processing. Its logic-based approach to problem-solving makes it a unique language to learn and use. In this guide, we covered the basics of Prolog programming, including its syntax, structure, and applications. We also provided an example program to illustrate how Prolog can be used to solve problems.