Clojure is a dynamic, modern programming language that is designed to be practical and efficient for programming large-scale, concurrent, and distributed systems. Clojure is built on top of the Java Virtual Machine (JVM), which allows for easy integration with existing Java code, making it a popular choice for developers who want to build robust and scalable applications. In this beginner's guide to Clojure, we'll dive into the history of the language, its syntax, and some of its most common applications.

History:
Clojure was first created in 2007 by Rich Hickey, a software developer who was frustrated with the limitations of traditional programming languages. Hickey was inspired by the functional programming concepts of Lisp, but he wanted to create a language that was more modern and practical for building real-world applications. Hickey designed Clojure to be simple, efficient, and highly expressive, with a strong focus on immutability and concurrency.

Syntax:
Clojure has a simple, uniform syntax that is based on S-expressions, which are a way of representing nested data structures. In Clojure, code is organized into functions, which can be defined using the "defn" keyword. Functions can take arguments, which are passed in using parentheses, and they can return values using the "return" keyword. Here's an example of a simple Clojure function that adds two numbers together:

```clojure
(defn add [a b]
  (+ a b))
```

This function is defined using the "defn" keyword, and it takes two arguments, "a" and "b". Inside the function, we use the "+" operator to add the two numbers together and return the result.

Applications:
Clojure is a popular choice for building large-scale, distributed systems, as well as for data analysis and processing. Clojure's focus on immutability and concurrency makes it well-suited for handling large amounts of data in parallel, which is important for many real-world applications. Some of the most common applications of Clojure include:

- Web development: Clojure is commonly used for building web applications, thanks to its support for server-side programming and its integration with popular web frameworks like Ring and Compojure.
- Data analysis: Clojure is well-suited for working with large datasets, thanks to its support for functional programming and its built-in support for working with data structures like maps and vectors.
- Gaming: Clojure's support for functional programming and its performance on the JVM make it a popular choice for building video games and interactive applications.

Conclusion:
Clojure is a powerful and expressive programming language that is well-suited for building large-scale, distributed systems. Its focus on immutability and concurrency make it well-suited for handling large amounts of data in parallel, and its support for functional programming and S-expressions make it easy to write expressive and concise code. Whether you're a web developer, data analyst, or game developer, Clojure has something to offer, and it's definitely worth exploring if you're looking for a modern and efficient programming language.